A U-shaped association between composite dietary antioxidant index and migraine in US adults: a nationwide cross-sectional study.

Background:Methods:Results:Conclusions:The field of dietary therapies for migraine has grown in popularity. Less research has been conducted to establish the relationship between migraine and the composite dietary antioxidant index (CDAI), a crucial indicator for evaluating the overall combined effects of multiple dietary antioxidants. Therefore, this study addressed this gap based on the National Health and Nutrition Examination Survey (NHANES) database.Multivariate logistic regression equations were used to investigate the relationship between CDAI and migraine, and smoothed-fitted curves were plotted. After a nonlinear relationship was discovered, the recursive algorithm and a two-stage linear regression model were employed to calculate the turning point. Additional stratified analyses were performed to explore differences between populations.This study included a total of 9,190 participants aged 20 years old or older. A U-shaped association was observed between the CDAI and migraine, with an inflection point of 0.2. They were negatively correlated before the inflection point with OR of 0.93 (95% CI = 0.88–0.97) and positively correlated after the inflection point with OR of 1.04 (95% CI = 1.01–1.07). This U-shaped relationship persisted among people aged <60 and ≥60 years, women, and people with BMI <30 and ≥30.We identified a U-shaped association between CDAI and migraine in the U.S. adult population. Further case–control studies and experimental research are needed to explore the underlying mechanisms of action. [ABSTRACT FROM AUTHOR]