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Obesity, white adipose tissue and cancer.

Obesity, white adipose tissue and cancer.

Authors :
Solsona‐Vilarrasa, Estel
Vousden, Karen H.
Source :
FEBS Journal. Nov2024, p1. 19p. 6 Illustrations.
Publication Year :
2024

Abstract

White adipose tissue (WAT) is crucial for whole‐body energy homeostasis and plays an important role in metabolic and hormonal regulation. While healthy WAT undergoes controlled expansion and contraction to meet the body's requirements, dysfunctional WAT in conditions like obesity is characterized by excessive tissue expansion, alterations in lipid homeostasis, inflammation, hypoxia, and fibrosis. Obesity is strongly associated with an increased risk of numerous cancers, with obesity‐induced WAT dysfunction influencing cancer development through various mechanisms involving both systemic and local interactions between adipose tissue and tumors. Unhealthy obese WAT affects circulating levels of free fatty acids and factors like leptin, adiponectin, and insulin, altering systemic lipid metabolism and inducing inflammation that supports tumor growth. Similar mechanisms are observed locally in an adipose‐rich tumor microenvironment (TME), where WAT cells can also trigger extracellular matrix remodeling, thereby enhancing the TME's ability to promote tumor growth. Moreover, tumors reciprocally interact with WAT, creating a bidirectional communication that further enhances tumorigenesis. This review focuses on the complex interplay between obesity, WAT dysfunction, and primary tumor growth, highlighting potential targets for therapeutic intervention. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1742464X
Database :
Academic Search Index
Journal :
FEBS Journal
Publication Type :
Academic Journal
Accession number :
180647979
Full Text :
https://doi.org/10.1111/febs.17312