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Physicochemical and structural analysis of N-phenylacetyl-L-prolylglycine ethyl ester (Noopept) – An active pharmaceutical ingredient with nootropic activity.

Authors :
Araj, Szymon Kamil
Szeleszczuk, Łukasz
Gubica, Tomasz
Zielińska-Pisklak, Monika
Bethanis, Kostas
Christoforides, Elias
Dudek, Marta Katarzyna
Pisklak, Dariusz Maciej
Source :
Journal of Pharmaceutical & Biomedical Analysis. Jan2025, Vol. 252, pN.PAG-N.PAG. 1p.
Publication Year :
2025

Abstract

N -Phenylacetyl-L-prolylglycine ethyl ester (Noopept, GVS-111, omberacetam) is an orally available active pharmaceutical ingredient (API), with neuroprotective properties and ability to enhance cognitive function. It belongs to nootropic family of drugs and is included in the group of racetams, although its chemical structure is quite different than the other compounds from this group, including the most popular one – piracetam. The mechanism of action of this API is multifaced and is considered to be involving modulation of various neurotransmitter systems within the brain. Despite the significant amount of works devoted to the pharmacodynamics of Noopept, very little is known about its structural and physicochemical properties. Therefore, the aim of current study was to investigate this API in a very thorough way. In this work, the detailed physicochemical analysis of Noopept has been done using TGA/DSC, 1H and 13C liquid state NMR, 13C CP/MAS NMR, SEM, SCXRD, and PXRD. Additionally, quantum chemical DFT computations under periodic boundary conditions, using CASTEP, were conducted to facilitate the analysis of experimental results. Besides, we've performed a polymorphism screening of this molecule. • Detailed physicochemical analysis of Noopept has been performed. • Crystal structure of Noopept was determined using SCXRD. • Polymorph screening has been performed for Noopept. • Periodic DFT calculations were used for analysis NMR and FT-IR spectra of Noopept. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
07317085
Volume :
252
Database :
Academic Search Index
Journal :
Journal of Pharmaceutical & Biomedical Analysis
Publication Type :
Academic Journal
Accession number :
180629456
Full Text :
https://doi.org/10.1016/j.jpba.2024.116474