Multiple drugs: Lack of efficacy: 2 case reports.

The article in Reactions Weekly describes two case reports of men aged 64-66 with extensive stage small cell lung cancer who exhibited lack of efficacy during treatment with various drugs. Patient 1 initially responded well to traditional chemotherapy but later experienced worsened symptoms with catequentinib. Patient 2 also showed lack of efficacy to etoposide, cisplatin, and tislelizumab, eventually leading to his death in September 2022. The article provides detailed accounts of the treatment courses and outcomes for both patients, highlighting the challenges in managing advanced lung cancer. [Extracted from the article]