Back to Search Start Over

Effectiveness of 8-week TReatment with vortioxetine on depressive symptoms in major depressive disorder patients with comorbid generalized anxiety disorder in UAE (TRUE).

Authors :
Badr, Bassem
Gailani, Hana Al
Alkhoori, Samia
Butt, Hania
Daher, Michel
Dheyaa, Bassam
Hindy, Nasser El
Eid, Mohamed Wafeek
Elsaadouni, Nisrin
Faia, Valentina
Haweel, Alaa
Khammas, Tarek
Omar, Hussein
Tadros, George
Yacoub, Charles
Talaat, Tamer
El-Shafei, Ahmed
Source :
Annals of General Psychiatry. 11/1/2024, Vol. 23 Issue 1, p1-10. 10p.
Publication Year :
2024

Abstract

Background: Major Depressive Disorder (MDD) is a leading cause of disability and results in excessive utilization of healthcare resources worldwide. The Middle East and North Africa (MENA) region shows a high prevalence of depressive disorders. Generalized Anxiety Disorder (GAD) and MDD have the highest rate of comorbidity of all mood and anxiety disorders, ranging from 40 to 98% in drug studies. Comorbid GAD results in more significant impairment in MDD and increases the severity of symptoms. Although several clinical trials supported the safety and effectiveness of vortioxetine, no data regarding these aspects has been revealed in the MENA region. This study aimed to assess the safety and efficacy of vortioxetine in patients with comorbid GAD in the United Arab Emirates (UAE). Method: In a multicenter observational study, 118 patients with confirmed anxiety and depressive disorders were evaluated over four visits (baseline visit, two weeks, four weeks, and eight weeks) using MADRS and HAM-A scales to assess depression and anxiety severity, respectively by calculating mean change and the percent using Kendall's W test. Results: A significant mean difference in MADRS score was observed, with a gradual decrease of mean MADRS total scores over the assessment weeks (p < 0.001) as well as in HAM-A scores, from severe to moderate-severe anxiety through the four visits (p < 0.001). Furthermore, only one case was reported as a serious side effect. Nausea and insomnia were the most predominant side effects reported among the studied population. Conclusion: Vortioxetine was found effective and safe among patients with MDD and comorbid GAD. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1744859X
Volume :
23
Issue :
1
Database :
Academic Search Index
Journal :
Annals of General Psychiatry
Publication Type :
Academic Journal
Accession number :
180626446
Full Text :
https://doi.org/10.1186/s12991-024-00526-w