经胸超声引导下卵圆孔未闭封堵术在合并冠心病患者中的治疗效果和安全性.

Objective To explore the treatment effects and safety of transthoracic ultrasound-guided closure combined with percutaneous coronary intervention (PCI) in patients with coronary artery disease and patent foramen ovale (PFO). Methods A retrospective analysis was conducted on the clinical data of 110 patients who underwent PFO closure combined with PCI from February 2021 to March 2024. Among them, 50 patients underwent X-ray-guided PFO closure (X-ray group), and 60 patients underwent transthoracic echocardiography (TTE) -guided PFO closure (TTE group). The study compared perioperative cardiac function indices, shunt status, complication rates, and adverse events during follow-up, including bleeding, paradoxical embolism, myocardial infarction, sudden death, and stroke.Results There were no significant differences in closure time, PCI time, and hospital stay between the TTE and X-ray groups (P＞0.05). Post-treatment, cardiac function indices improved in both groups compared to pre-treatment (P＜0.05), with no significant differences between groups (P＞0.05). Shunt status also improved post-treatment (P＜0.05), but differences between groups were not statistically significant (P＞0.05). The complication and adverse event rates were similar between the two groups (P＞0.05). The Log-rank test indicated no significant difference in clinical event-free survival between TTE-guided and X-ray-guided PFO closure combined with PCI (HR=0.783, 95% CI: 0.324-1.895, P=0.582). Conclusion For patients with PFO and coronary artery disease, TTE-guided PFO closure combined with PCI is as safe and feasible as X-ray-guided methods. TTE procedures can help reduce radiation exposure in clinical settings while maintaining good safety. [ABSTRACT FROM AUTHOR]