Targeting senescent cells in atherosclerosis: Pathways to novel therapies.

Targeting senescent cells has recently emerged as a promising strategy for treating age-related diseases, such as atherosclerosis, which significantly contributes to global cardiovascular morbidity and mortality. This review elucidates the role of senescent cells in the development of atherosclerosis, including persistently damaging DNA, inducing oxidative stress and secreting pro-inflammatory factors known as the senescence-associated secretory phenotype. Therapeutic approaches targeting senescent cells to mitigate atherosclerosis are summarized in this review, which include the development of senotherapeutics and immunotherapies. These therapies are designed to either remove these cells or suppress their deleterious effects. These emerging therapies hold potential to decelerate or even alleviate the progression of AS, paving the way for new avenues in cardiovascular research and treatment. • In-depth Mechanistic Study : Reveal the mechanisms by which senescent cells contribute to the progression of AS. • Evaluation of Multiple therapeutic Strategies : Senolytic and senomorphic drugs in the treatment of AS. • Innovative Immunotherapy Prospects : Summarize the application of anti-senescence drugs and the prospects of immunotherapy. • Interdisciplinary Approaches : Bioinformatics and AI methods can identify potential targets and optimize strategies. [ABSTRACT FROM AUTHOR]