Of Strong Swords and Fine Scalpels: Developing Robust Clinical Principles to Cut Through Heterogeneity.

This is an invited commentary article for the special issue. The main thesis is that an effective strategy for computational psychiatry to handle the (possibly intrinsic) heterogeneity of psychiatric disorders is to focus on developing clinical principles rather than solely precision medicine. General Scientific Summary: The field of computational psychiatry has overwhelmingly focused on the goal of precision medicine (a "fine-scalpels" approach). I argue for reallocating some effort toward deriving potent clinical principles to improve psychological treatments (a "strong-swords" approach)—a worthwhile goal in its own right with an established track record. I draw on an example from my research program to illustrate the strong-swords approach. [ABSTRACT FROM AUTHOR]