Back to Search Start Over

Differentiation of Ayahuasca Samples According to Preparation Mode and Botanical Varieties Using Metabolomics.

Authors :
Matos, Taynara Simão
da Silva Zandonadi, Flávia
Rosini Silva, Alex Aparecido
Dias Soares, Stephanie
de Souza Lima, Adriana
Pastore, Glaucia Maria
de Melo Porcari, Andreia
Sussulini, Alessandra
Source :
Journal of Psychoactive Drugs. Oct2024, p1-10. 10p. 4 Illustrations.
Publication Year :
2024

Abstract

Ayahuasca is a brew traditionally prepared with a mixture of <italic>Psychotria viridis</italic> leaves and <italic>Banisteriopsis caapi</italic> vine and has demonstrated therapeutic properties for depression. Knowledge of the brew composition is important to improve the therapeutic potential and decrease side effects if ayahuasca becomes an option for refractory depression treatment. Ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) was applied to analyze 126 ayahuasca samples collected from different <italic>ayahuasqueiro</italic> groups and geographic origins. We were able to observe a differentiation in the metabolite composition of ayahuasca samples prepared by diverse <italic>ayahuasqueiro</italic> groups. These samples presented different antioxidant effects based on FRAP and ORAC assays. Exploratory statistical analysis demonstrated a trend of separating the samples according to the religious group. The most important identified compounds for differentiation of the brew prepared by distinct religious groups are glycosylated and/or phenolic compounds. The comparison based on the mode of ayahuasca preparation presented more variability than the comparison based on the botanical variety of <italic>B. caapi</italic> used. We conclude that ayahuasca samples prepared with “caupuri” or “tucunacá” separately exhibited differences in the analysis of L-glutamate and the metabolism of arginine and proline. This suggests that a possible variation in this pathway could explain the occurrence of swollen stem nodes in “caupuri,” one of the <italic>B. caapi</italic> varieties. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02791072
Database :
Academic Search Index
Journal :
Journal of Psychoactive Drugs
Publication Type :
Academic Journal
Accession number :
180543862
Full Text :
https://doi.org/10.1080/02791072.2024.2420059