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Lesional Psoriasis is Associated With Alterations in the Stratum Corneum Ceramide Profile and Concomitant Decreases in Barrier Function.

Authors :
Rousel, Jannik
Mergen, Catherine
Bergmans, Menthe E.
Klarenbeek, Naomi B.
der Kolk, Tessa Niemeyer‐van
van Doorn, Martijn B. A.
Bouwstra, Joke A.
Rissmann, Robert
Hankemeier, Thomas
Vreeken, Rob
van Beugen, Sylvia
van Laarhoven, Antoinette
Balak, Deepak
Lelieveldt, Boudewijn
El Ghalbzouri, Abdoel
Seyger, Marieke
van den Reek, Juul
van den Bogaard, Ellen
de Jong, Elke
van Smeden, Jeroen
Source :
Experimental Dermatology. Oct2024, Vol. 33 Issue 10, p1-13. 13p.
Publication Year :
2024

Abstract

Psoriasis is an inflammatory skin disease associated with an impaired skin barrier. The skin barrier function is dependent on the extracellular lipid matrix which surrounds the corneocytes in the stratum corneum. Ceramides comprise essential components of this matrix. Alterations in the stratum corneum ceramide profile have been directly linked to barrier dysfunction and might be an underlying factor of the barrier impairment in psoriasis. In this study, we investigated the ceramide profile and barrier function in psoriasis. Lesional and non‐lesional skin of 26 patients and 10 healthy controls were analysed using in‐depth ceramide lipidomics by liquid chromatography‐mass spectrometry. Barrier function was assessed by measuring transepidermal water loss. Lesional skin showed a significant decrease in the abundance of total ceramides with significant alterations in the ceramide subclass composition compared to control and non‐lesional skin. Additionally, the percentage of monounsaturated ceramides was significantly increased, and the average ceramide chain length significantly decreased in lesional skin. Altogether, this resulted in a markedly different profile compared to controls for lesional skin, but not for non‐lesional skin. Importantly, the reduced barrier function in lesional psoriasis correlated to alterations in the ceramide profile, highlighting their interdependence. By assessing the parameters 2 weeks apart, we are able to highlight the reproducibility of these findings, which further affirms this connection. To conclude, we show that changes in the ceramide profile and barrier impairment are observed in, and limited to, lesional psoriatic skin. Their direct correlation provides a further mechanistic basis for the concomitantly observed impairment of barrier dysfunction. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09066705
Volume :
33
Issue :
10
Database :
Academic Search Index
Journal :
Experimental Dermatology
Publication Type :
Academic Journal
Accession number :
180521034
Full Text :
https://doi.org/10.1111/exd.15185