Research progress on role of MFG-E8 in regulating function of microglia.

Microglia are resident immune cells in the central nervous system(CNS), it play an important role in both physiological and pathological conditions of the CNS, and can be activated by a variety of physicochemical factors to produce pro-inflammatory phenotype (M1 type) and anti-inflammatory phenotype (M2 type). Milk fat globule epidermal growth factor 8(MFG-E8) is closely related to the biological function of microglia, which can regulate microglia neuroprotective effects such as promoting phagocytosis, anti-inflammatory, and inhibiting oxidative stress in CNS related diseases. It also regulates microglia pro-tumor effect, which in turn affects the outcome of the disease. This article reviews the role of targeting MFG-E8 in regulating the function of microglia, and provides a basis for finding therapeutic targets for CNS related diseases in the future. [ABSTRACT FROM AUTHOR]