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Host–diet–microbiota interplay in intestinal nutrition and health.

Authors :
Ignatiou, Anastasia
Pitsouli, Chrysoula
Source :
FEBS Letters. Oct2024, Vol. 598 Issue 20, p2482-2517. 36p.
Publication Year :
2024

Abstract

The intestine is populated by a complex and dynamic assortment of microbes, collectively called gut microbiota, that interact with the host and contribute to its metabolism and physiology. Diet is considered a key regulator of intestinal microbiota, as ingested nutrients interact with and shape the resident microbiota composition. Furthermore, recent studies underscore the interplay of dietary and microbiota‐derived nutrients, which directly impinge on intestinal stem cells regulating their turnover to ensure a healthy gut barrier. Although advanced sequencing methodologies have allowed the characterization of the human gut microbiome, mechanistic studies assessing diet–microbiota–host interactions depend on the use of genetically tractable models, such as Drosophila melanogaster. In this review, we first discuss the similarities between the human and fly intestines and then we focus on the effects of diet and microbiota on nutrient‐sensing signaling cascades controlling intestinal stem cell self‐renewal and differentiation, as well as disease. Finally, we underline the use of the Drosophila model in assessing the role of microbiota in gut‐related pathologies and in understanding the mechanisms that mediate different whole‐body manifestations of gut dysfunction. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00145793
Volume :
598
Issue :
20
Database :
Academic Search Index
Journal :
FEBS Letters
Publication Type :
Academic Journal
Accession number :
180503057
Full Text :
https://doi.org/10.1002/1873-3468.14966