Lab-in-syringe as a practical technique for automatic microextraction: Evaluation by Blue Applicability Grade Index.

Lab-in-syringe (LIS) is a powerful automatic technique that is derived from sequential injection analysis. In LIS, a computer-controlled syringe pump is employed, and its syringe barrel serves as a mixing, reaction, and/or extraction chamber. Until now, the LIS concept has been efficiently employed for the automation of solid-phase microextraction and liquid-phase microextraction protocols as a front-end to a plethora of chromatographic and spectrometric techniques. In this work, the applicability of LIS systems was examined using the Blue Applicability Grade Index (BAGI), a recently introduced metric tool that is used to examine the applicability of an analytical method. For this purpose, the sample preparation procedure and the instrumental method are thoroughly evaluated. The attained BAGI scores ranged between 60.0 and 77.5 for all the examined methods, while the average score was 71.3. As derived from the BAGI evaluation, good practicality can be attributed to the reviewed systems and protocols. • Evaluation of 32 LIS systems using BAGI meric tool. • All LIS systems showed high applicability in terms of practicality. • The average BAGI score for LPME and headspace methods was 72.7. • The average BAGI score for SPE-based methods was 67.2. [ABSTRACT FROM AUTHOR]