Mesenchymal stem cells with an enhanced antioxidant capacity integrate as smooth muscle cells in a model of diabetic detrusor underactivity.

The article explores the use of mesenchymal stem cells (MSCs) with enhanced antioxidant capacity in treating diabetic detrusor underactivity (DUA). The study investigates the mechanisms and optimal protocols of MSC transplantation in a preclinical model of diabetic DUA, highlighting the importance of the HGF-MET pathway and PD-L1 in muscle regeneration and immunomodulation. The research demonstrates the therapeutic efficacy of human umbilical-cord derived MSCs with enhanced antioxidant capacity in alleviating tissue injury, contributing to muscle regeneration and immunomodulation in diabetic DUA, offering a promising approach for stem cell therapies. [Extracted from the article]