Graphene oxide functionalized with silatrane as probe for electrochemical recognition of acetaminophen in pharmaceuticals tablets.

The present article involves synthesis of graphene oxide functionalized silatrane for the electrochemical detection of acetaminophen. [Display omitted] • Graphene oxide functionalized silatrane (GO-Silatrane) based sensor has been synthesized. • Electrochemical study of the prepared probe shows sensitive and selective attraction towards acetaminophen. • GO-Silatrane/GCE shows excellent reproducibility and repeatability. • The practical applicability of the receptor has been checked by detecting it in pharmaceutical tablets. Acetaminophen, commonly known as paracetamol, is a widely used analgesic and antipyretic drug that is frequently found in over-the-counter and prescription medications. Due to its extensive use, precise monitoring of acetaminophen levels is crucial for ensuring patient safety, especially to prevent accidental overdoses which can lead to severe liver damage. In this study, a novel electrochemical sensor based on graphene oxide (GO) functionalized with silatrane was developed for the detection of acetaminophen. The hybrid material was synthesized and electrodeposited on a glassy carbon electrode, providing a highly selective, sensitive, and reproducible platform for acetaminophen detection. The sensor exhibited a linear detection range from 2.5 to 100 μM with a limit of detection of 84.8 nM. The effectiveness of this GO-based sensing platform was demonstrated through the successful quantification of acetaminophen in pharmaceutical tablets such as Dolo 650, Paracip, and Crocin. The results highlight the potential application of this sensor in quality control and safety monitoring of pharmaceutical formulations, ensuring accurate determination of acetaminophen content. [ABSTRACT FROM AUTHOR]