Magnetically actuated cisplatin-loaded nanoparticle collectives enhance drug penetration for potentiated ovarian cancer chemotherapy.

We propose a strategy utilizing magnetic nanoparticle collectives to enhance drug targeted delivery and penetration for potentiated ovarian cancer chemotherapy. The designed magnetic pH-responsive nanoparticle collectives could active deliver chemotherapeutics to the tumor site, and enhance drug penetration into deep tumors by the torque-force hybrid magnetic field, offering potentially clinically feasible strategy for enhancing tumor chemotherapy. [Display omitted] Chemotherapy is the main clinical treatment for ovarian cancer, but still faces challenges of low drug targeting efficiency and insufficient drug permeability. Drug-loaded nanoparticle collectives, which are actuated by magnetic field, could be targeted to a designated location and achieve targeted drug delivery. In this work, we report a strategy that utilizes magnetic mesoporous silica nanoparticles loaded with cis -diaminodichloroplatinum (Fe 3 O 4 @SiO 2 -CDDP) for targeted delivery of chemotherapeutic drugs and enhances penetration into deep tumors. The Fe 3 O 4 @SiO 2 -CDDP collectives actively moved to the target tumor site, and this movement was regulated by a magnetic actuation system. Under the action of a torque-force hybrid magnetic field (TFMF), Fe 3 O 4 @SiO 2 -CDDP could further penetrate into the interior of tumors and achieve pH-responsive drug release in the tumor environment. The feasibility of this strategy was verified in three-dimensional cell spheres in vitro and in a tumor-bearing mouse model in vivo. This magnetically actuated nanoparticle collectives enhanced drug penetration strategy provides a new paradigm for targeted drug delivery and potentiated tumor therapy. [ABSTRACT FROM AUTHOR]