Simple formula for adjusted performance parameters in evaluation of diagnostic methods.

The article discusses the importance of adjusting performance parameters in evaluating diagnostic methods to account for sample size. Existing performance parameters like accuracy, sensitivity, and specificity may be misleading when sample size is not considered. Adjusted performance parameters, which incorporate the estimated performance and uncertainty, provide a more reliable evaluation of a method's performance, especially in studies with small sample sizes. The proposed adjustment allows for a better comparison of different methods and a more realistic assessment of method performance, particularly in cases of 100% accuracy. [Extracted from the article]