Cyclophosphamide/rituximab/steroids: Lack of efficacy: 3 case reports.

The article in Reactions Weekly discusses three case reports of adult men with primary T-cell CNS lymphoma who showed lack of efficacy during treatment with steroids, rituximab, and cyclophosphamide. Despite receiving this treatment, all three patients experienced worsening conditions. The patients had prominent Susceptibility Weighted Imaging changes on MRI brain, multiple areas of microhaemorrhages, and positive monoclonal populations in T-cell receptor gamma gene rearrangement. Brain biopsies showed nonspecific reactive changes with various differential diagnoses. [Extracted from the article]