Synthesis and characterization of octahedron and cube shape Mn0.5Zn0.5Fe2O4 particle dispersion for magnetic fluid hyperthermia.

The present work reports a synthesis of octahedron (A55NO) and cube-shaped (A55NC) Mn 0.5 Zn 0.5 Fe 2 O 4 ferrite nanoparticle dispersion in distilled water. The crystal structure analyzed using powder X-ray diffraction (XRD) shows the crystallite sizes of 17.7 ± 0.4 nm and 11.9 ± 1.0 nm, respectively, for the A55NO and A55NC particles. The morphology as seen from transmission electron microscopy (TEM) confirms 17.8 ± 0.3 nm (σ = 0.27) and 8.7 ± 0.3 nm (σ = 0.33) edge lengths, respectively, for octahedron and cube-shaped particles. The thermogravimetric analyzer (TGA) and Fourier transform infrared (FTIR) spectroscopy are used to confirm the chemical binding of the surfactant with a sharp transition at 208.67 °C and 218.32 °C, respectively, for octahedron and cube-shaped particles, indicating the removal of the surfactant due to its decomposition from the particle surface. Both the particles are highly magnetic and have 75.32 Am2/kg and 72.93 Am2/kg saturation magnetization, as revealed by their M − H loops using a vibrating sample magnetometer (VSM). The stability of the sample is confirmed using the particle size analyzer (DLS) and the Zeta potential analyzer. The induction heating capacity of the fluid was investigated using the Embrell Easy Heat model LA6310 at 330 kHz. The heating response shows that even a minimum concentration of 1 mg/mL is sufficient to achieve the hyperthermic window temperature of 42 °C for both samples, which, unlike the same composition prepared by other routes, makes it impossible to go beyond 38 °C. Moreover, octahedron particle dispersion can reach this window temperature within 10 min, whereas cube particle dispersion requires only 15 min. The findings of this study hold significant practical value since it confirms that Mn 0.5 Zn 0.5 Fe 2 O 4 composition with tuneable shape has the potential to work as a temperature-controlled magnetic switch for magnetic fluid hyperthermia under the defined safety limit with the minimum concentration. [ABSTRACT FROM AUTHOR]