ПОЛУЧЕНИЕ ВОДОРАСТВОРИМЫХ КОМПЛЕКСОВ ВКЛЮЧЕНИЙ ГИДРАЗИДОВ о- И п-ГИДРОКСИБЕНЗОЙНЫХ КИСЛОТ И ИХ ГИДРАЗОНОВЫХ ПРОИЗВОДНЫХ

The article presents the results of studies on obtaining water-soluble complexes of biologically active hydrazides and hydrazones derived from derivatives of o- and p-hydroxybenzoic acids. Hydrazones are widely used in medicine as antitubercular antibacterial and anti-inflammatory drugs, antiseptics, preservatives and other bioactive substrates. Most of them are characterized by low solubility in water, which limits their further study for biological activity. The paper shows that hydrazides of o- and p-hydroxybenzoic acids and their hydrazone derivatives can form various inclusion complexes with natural macromolecular biopolymers. The new hydrazone products considered in this article are able to dissolve in water and also form stable aqueous dispersions. Obtaining water-soluble complexes of these compounds can lead to an increase in their bioavailability, which, accordingly, will allow to significantly reduce their therapeutic concentration. Complexes between biopolymer and substrate molecules have been shown to be quite stable. In this case, the host complexing molecule will contribute to the protection of the substrate molecule from interaction with various highly reactive molecules, reducing the rate of oxidation, hydrolysis and/or degradation, as well as the probability of steric rearrangements and racemization. The new inclusion complexes of hydrazides and hydrazones of o- and p-hydroxybenzoic acids described in this work have been characterized by IR and NMR-1H spectroscopy, differential scanning thermogravimetry and scanning electron microscope. [ABSTRACT FROM AUTHOR]