Incidence of psychiatric disorders after total knee or hip arthroplasty by anesthesia type: A nationwide cohort study.

Evidence is lacking of an association between anesthetic choice and the risk of psychiatric disorders. Therefore, this study aimed to examine the impact of regional anesthesia (R/A) versus general anesthesia (G/A) on the occurrence of psychiatric disorders in patients undergoing total knee arthroplasty (TKA) or total hip arthroplasty (THA). Data for this population-based cohort study were sourced from the National Health Insurance Service of South Korea. The study included adult patients who underwent TKA or THA between January 1, 2016, and December 31, 2021. The endpoint was the diagnosis of postoperative psychiatric disorders within 1 year postoperative. This study included 411,967 patients who underwent THA or TKA. Among them, 290,476 (70.5 %) underwent THA or TKA under R/A (R/A group), while 121,491 (29.5 %) underwent THA or TKA under G/A (G/A group). In multivariate logistic regression, the R/A group had an 8 % lower incidence of postoperative psychiatric disorders (odds ratio [OR], 0.92; 95 % confidence interval [CI], 0.90–0.94; P < 0.001) than the G/A group. Specifically, a lower incidence of postoperative psychiatric disorder for depression (OR, 0.89; 95 % CI, 0.86–0.92; P < 0.001), bipolar disorder (OR, 0.88; 95 % CI, 0.83–0.94; P < 0.001), anxiety disorder (OR, 0.95; 95 % CI, 0.92–0.98; P = 0.001), and insomnia disorder (OR, 0.95; 95 % CI, 0.80–1.11; P = 0.496) was observed in the R/A versus G/A group. Among these South Korean patients who underwent TKA or THA, the R/A group had a lower incidence of postoperative psychiatric disorders than the G/A group. • Relationship between anesthesia and psychiatric disorder remain controversial. • General Anesthesia might be risk factor for development of psychiatric disorder. • Opting against General Anesthesia may contribute to preventing psychiatric disorders. [ABSTRACT FROM AUTHOR]