Airway Exposure to House Dust Mite Promotes the Development of Allergy to Egg White in Mice.

The article in Clinical & Experimental Allergy explores how exposure to house dust mite (HDM) can promote the development of allergy to egg white in mice. The study found that inhalation of egg white and HDM led to systemic Th2 responses in mice, indicating a potential link between respiratory exposure to food allergens and systemic sensitization. The research suggests that prior sensitization to egg proteins through the respiratory tract, facilitated by HDM components, could lead to food allergies when egg is later ingested. The study highlights the adjuvant activity of HDM in enhancing the development of a Th2-driven immune response to egg white through the airways, with protease activity playing a modest role in this context. [Extracted from the article]