急性冠状动脉综合征患者血清 CHOP, COMP, TN-C 与冠状动脉 病变程度和 PCI 术后 MACE 的关系.

Objective: To investigate the relationship between endoplasmic reticulum stress-related protein (CHOP), cartilage oligomeric matrix protein (COMP), tendone protein-C (TN-C) and the severity of coronary artery disease and major adverse cardiovascu- lar events (MACE) after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). Methods: 175 ACS patients admitted to our hospital from September 2020 to September 2022 were selected as observation group, and 50 healthy subjects who underwent physical examination in our hospital during the same period were selected as control group. The levels of CHOP, COMP and TN-C were detected and compared between two groups, and ACS patients were divided into mild, moderate and severe groups according to the severity of the disease, and the levels of various indicators were compared. All patients were treated with PCI, and fol- lowed up for 1 year after operation, the incidence of MACE was counted, and the levels of serum CHOP, COMP and TN-C in MACE group and non-MACE group were compared. The relationship between MACE and serum CHOP, COMP and TN-C in ACS patients after PCI were analyzed by univariate and multivariate Logistic regression models. Results: The levels of serum CHOP, COMP and TN-C in observation group were higher than those in control group (P<0.05). The levels of serum CHOP, COMP and TN-C in severe group were higher than those in moderate group and higher than those in mild group (P<0.05). 1 year after operation, the incidence of MACE was 23.43% (41/175), the levels of serum CHOP, COMP and TN-C in MACE group were higher than those in non-MACE group (P<0.05). By univariate analysis, the proportion of patients with New York Heart Association (NYHA) cardiac function grade III-IV, history of hypertension, history of diabetes and hyperlipidemia in MACE group was higher than that in non-MACE group (P<0.05). Logistic multivariate analysis showed that, high levels of CHOP, COMP, TN-C, NYHA cardiac function grade III-IV, history of hypertension, history of diabetes and hyperlipidemia were independent risk factors for MACE after PCI in ACS patients. Conclusion: Serum CHOP, COMP and TN-C show increase expression in ACS patients, and further increase with the aggravation of the patient's condition, and together with NYHA cardiac function classification and basic diseases, constitute independent risk factors for MACE after PCI in ACS patients. [ABSTRACT FROM AUTHOR]