血清 ANGPTL4, cTnI 及 mACEF 评分与冠心病患者 PCI 术风险 及术后临床结局的关系探究.

Objective: To explore the serum sample angiogenin protein 4 (ANGPTL4), cardiac troponin I (cTnI) and age,creatinine clearance, ejection fraction (m ACEF) score and coronary heart disease patients with percutaneous coronary intervention (PCI) risk and the relationship between the postoperative clinical outcome. Methods: From January 2020 to October 2022 in our hospital fou PCI surgery of 108 cases of coronary heart disease patients into the study, according to the European cardiac surgery risk assessment system (EuroSCORE) Ⅱ score evaluation PCI perioperative risk, divided into high-risk groups and high-risk groups. All patients were performed preoperative m ACEF score and EuroSCORE Ⅱ score, to detect serum ANGPTL4, cTnI expression level. Followed up for 12months, the record of cardiovascular adverse events. Comparing high-risk group and the high-risk group of serum ANGPTL4, cTnI and m ACEF score, analysis of serum ANGPTL4, cTnI and m ACEF score and EuroSCORE Ⅱ grading and the relationship between the prediction of cardiovascular adverse events. Results: The high-risk group of serum ANGPTL4, cTnI levels and m ACEF score were higher than in the high-risk group (P＜0.05). By the Pearson correlation analysis, patients with coronary heart disease ANGPTL4, cTnI levels and m ACEF score and serum EuroSCORE Ⅱ scores were positively correlated (P＜0.05). Routine PCI surgery in patients with coronary heart disease in 108, during a follow-up of 12 months, 20 cases of adverse cardiovascular events, accounted for 18.52%. Cardiovascular adverse events group serum ANGPTL4, cTnI levels and m ACEF score were higher than in non cardiovascular adverse events group (P＜0.05). After multiariable Logistic regression analysis, serum ANGPTL4, cTnI levels and m ACEF score is PCI postoperative patients with coronary heart disease independent factors affecting cardiovascular adverse events (P＜0.05). ROC curve analysis showed that serum ANGPTL4 and cTnI levels combined with m ACEF score were 90.32% sensitive, 52.37% specific and 0.901 AUC in predicting adverse cardiovascular events in patients with coronary heart disease after PCI. Conclusion: Serum ANGPTL4, cTnI and m ACEF score is closely related to the risk of patients with coronary heart disease (CHD) in PCI, combined prediction of postoperative clinical outcome performance is better. [ABSTRACT FROM AUTHOR]