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Dysregulation of the DRAIC/SBK1 Axis Promotes Lung Cancer Progression.
- Source :
-
Diagnostics (2075-4418) . Oct2024, Vol. 14 Issue 19, p2227. 12p. - Publication Year :
- 2024
-
Abstract
- Background: Long non-coding RNAs (lncRNAs) are key regulators of cellular processes that underpin cancer development and progression. DRAIC is a migration inhibitor that has been linked with lung adenocarcinoma progression; however, its mechanisms remain to be studied. Methods: Several bioinformatics tools were used to explore the role of DRAIC in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Results: Our bioinformatics analysis illustrates that patients with low expression of DRAIC have poor overall survival outcomes. In addition, the mRNA of SH3 domain-binding kinase 1 (SBK1) was downregulated in this cohort of patients. Mechanistic analysis showed that SBK1 is under the DRAIC competing endogenous RNAs network, potentially through sponging of miRNA-92a. Conclusions: Consistent dysregulation of the DRAIC-SBK1 axis was linked to poor survival outcome in both LUAD and LUSC, suggesting a tumour inhibitor role and providing potential for new diagnostics and therapeutic approaches. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COMPETITIVE endogenous RNA
*LINCRNA
*SURVIVAL rate
*OVERALL survival
*LUNG cancer
Subjects
Details
- Language :
- English
- ISSN :
- 20754418
- Volume :
- 14
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Diagnostics (2075-4418)
- Publication Type :
- Academic Journal
- Accession number :
- 180271267
- Full Text :
- https://doi.org/10.3390/diagnostics14192227