Hydroxyurea in Sickle Cell Disease and Invasive Bacterial Infections: A Case–Control Study.

Hydroxyurea decreases painful events among children with sickle cell disease (SCD) but could increase the risk of infections in treated patients through leucopenia. We performed a case–control study, comparing hydroxyurea treatment for SCD in cases with an invasive bacterial infection and in controls without infection. No difference was found. [ABSTRACT FROM AUTHOR]