Unveiling the Mechanism: Injectable Poly‐L‐Lactic Acid's Evolving Role—Insights From Recent Studies.

The article "Unveiling the Mechanism: Injectable Poly-L-Lactic Acid's Evolving Role—Insights From Recent Studies" in the Journal of Cosmetic Dermatology delves into the use of Sculptra poly-L-lactic acid in aesthetic dermatology to address volume loss, skin laxity, and wrinkles. It examines how PLLA stimulates collagen production, triggers adipogenesis, and promotes new extracellular matrix formation, potentially increasing volume in treated areas. The research suggests a complex relationship between PLLA, fibroblasts, macrophages, and adipocytes in achieving desired aesthetic outcomes, with unanswered questions remaining about PLLA's cell recognition mechanism. Further studies are needed to comprehend PLLA's effects on adipogenesis, immunological responses, angiogenesis, and interactions with other cells. The study was funded by Galderma, and the data are publicly accessible on PubMed. [Extracted from the article]