不同物种肌动蛋白聚合功能及其差异分析.

Actin polymerization is a crucial process in cellular functions, impacting key processes like cell division, development, morphogenesis, motility, and polarity establishment. Abnormalities in actin polymerization can lead to various diseases, including cancer, highlighting its significance in both normal cell function and disease progression. While the amino acid sequences of actin are highly conserved across species, recent studies have revealed differences in their polymerization functions. The animal or plant actin can be used heterologously in yeast cells, but certain types like the rabbit skeletal muscle and maize pollen actin have unique polymerization properties. On the other hand, the yeast actin can interact with the animal or plant actin. This review explores the polymerization characteristics of the animal, plant, and yeast actin, highlighting functional disparities in polymerization both in vivo and in vitro. Additionally, we discuss drugs that target actin polymerization, aiming to offer potential avenues for treating human diseases and advancing our understanding of actin's molecular mechanisms. Further research in this area may uncover the underlying principles of actin diversity and functional evolution, providing valuable insights for related fields. [ABSTRACT FROM AUTHOR]