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Multiplane Spectroscopic Whole‐Body Photoacoustic Computed Tomography of Small Animals In Vivo.

Authors :
Yang, Jinge
Choi, Seongwook
Kim, Jiwoong
Lee, Jihye
Kim, Won Jong
Kim, Chulhong
Source :
Laser & Photonics Reviews. Oct2024, p1. 12p. 6 Illustrations.
Publication Year :
2024

Abstract

To understand complex biological process and disease progression, it is essential to comprehensively track biodynamics across entire organisms. The invaluable tracking tool, photoacoustic computed tomography (PACT), provides insights into structural, functional, and molecular aspects of living tissues. However, current small‐animal PACT systems suffer from low temporal/spatial resolution and a restricted field of view, and they are limited in the biological information they can provide, hindering research on whole‐body biodynamics. Here, it is demonstrated a continuous rotary‐scanning PACT system for rapid monitoring of various parameters within the relatively large torso of a small animal. In this PACT system, a hemispherical transducer array is continuously rotated at high speed, enabling a 3D scan of an entire mouse body in just 54 s, with a spatial resolution of 172–212 µm. The rapid rotary scanning allows us to not only image whole‐body structures but also to monitor pharmacokinetics and changes in hemoglobin oxygen saturation in living animals. This approach holds great promise for advancing the understanding of in vivo biological dynamics, opening up a new avenue of preclinical research in areas such as metabolic diseases and drug delivery. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
18638880
Database :
Academic Search Index
Journal :
Laser & Photonics Reviews
Publication Type :
Academic Journal
Accession number :
180187738
Full Text :
https://doi.org/10.1002/lpor.202400672