越鞠丸合毓麟珠汤对多囊卵巢综合征不孕症患者 脂代谢和 HPA 轴功能的影响.

OBJECTIVE: To observe the therapeutic effect of Yueju pills combined with Yulinzhu decoction in the treatment of infertility of polycystic ovary syndrome (PCOS) and its effects on lipid metabolism and hypothalamicpituitary-adrenal (HPA) axis. METHODS: A total of 100 patients with infertility of PCOS admitted into the hospital from Jan. 2020 to Jun. 2022 were extracted to be divided into the control group and observation group via the random number table method, with 50 cases in each group. The control group was given conventional Western medicine orally, while the observation group was given Yueju pills combined with Yulinzhu decoction based on the control group. The clinical efficacy of both groups was evaluated after 3 menstrual cycles of treatment, traditional Chinese medicine (TCM) symptoms of both groups before and after treatment were scored, the serum lipid metabolism indicators [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C)] and HPA axis-related indicators [ follicle-stimulating hormone (FSH), luteinising hormone (LH), adrenocorticotrophic hormone (ACTH) and growth hormone (GH)] levels were detected, the number of mature follicles, score of cervical mucus and endometrial thickness during ovulation of both groups were observed. RESULTS: Compared with before treatment, the TCM symptom scores decreased significantly after treatment, the serum TG, TC and LDL-C levels decreased significantly, the serum FSH, LH and ACTH levels decreased significantly, the serum HDL-C and GH levels increased significantly, the numbers of mature follicles, scores of cervical mucus and endometrial thickness during ovulation increased significantly in both groups after treatment, with statistically significant differences (P<0. 05). The improvements of TCM symptom scores, serum lipid metabolism, HPA axis-related indicators and ovulation indicators in the observation group were better than those in the control group, with statistically significant differences (P<0. 05). The clinical total effective rate of the observation group was 90. 0% (45/50), significantly higher than 76. 0% (38/50) of the control group, with statistically significant difference (P<0. 05). CONCLUSIONS: The adjuvant treatment of Yueju pills combined with Yulinzhu decoction can effectively relieve the symptoms of patients with infertility of PCOS, improve ovarian function, regulate lipid metabolism level and HPA axis dysfunction, which has better effects than Ethinylestradiol cyproterone tablets alone. [ABSTRACT FROM AUTHOR]