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Vertebral Fractures Increase the Long-Term Mortality of Patients with Coronavirus Disease 2019.
- Source :
-
Endocrinology Research & Practice . Oct2024, Vol. 28 Issue 4, p197-204. 8p. - Publication Year :
- 2024
-
Abstract
- Objective: To investigate the impact of vertebral fracture (VF) on long-term mortality of patients with COVID-19. Methods: In this single-center retrospective study, patients with COVID-19 who were admitted during the first wave of the pandemic and who had undergone a thorax computerized tomography scan were consecutively included. Patients with VFs due to trauma or malignancy were excluded. A Multivariate Cox proportional hazard model was used for survival analyses. Results: Of the 349 patients, 249 (71.3%) had at least one VF. Patients with VF were older (55.3 ± 15 vs. 43.4 ± 13.3, P < .001) and had higher rates of diabetes mellitus (19.7% vs. 11%), hypertension (34.1% vs. 17%), dyslipidemia (11.6% vs. 4%), cardiovascular disease (15.3% vs. 6.1%), and acute kidney injury (23.5% vs. 13%) (P < .05 for all). The mean survival was lower in patients with VF (1285.6 days, SE: 24.3, 95% CI [1238-1333]) compared to patients without VF (1388.6 days, SE: 16.3, 95% CI [1356-1420]) (P = .024). The mean survival was particularly decreased in patients with moderate-severe (1168 days, P = .001) or multiple VFs (1276 days, P = .016). The association between VF and mortality was adjusted for diabetes mellitus, hypertension, cardiovascular and renal failure. Multivariate Cox proportional hazard model showed that malignancy, renal failure, and VFs were independent predictors of decreased survival. Conclusion: Vertebral fractures were found to be one of the most common comorbidities in patients with COVID-19. It also represents a potential marker of frailty and an important predictor of decreased survival. Vertebral fractures should be considered in all patients who have had COVID-19. The causal link between VFs and mortality requires large-scale prospective research. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RISK assessment
*ACADEMIC medical centers
*T-test (Statistics)
*DEATH
*KRUSKAL-Wallis Test
*VERTEBRAL fractures
*RETROSPECTIVE studies
*MULTIVARIATE analysis
*DESCRIPTIVE statistics
*REVERSE transcriptase polymerase chain reaction
*QUANTITATIVE research
*MANN Whitney U Test
*CHI-squared test
*KAPLAN-Meier estimator
*MEDICAL records
*ACQUISITION of data
*ANALYSIS of variance
*SURVIVAL analysis (Biometry)
*CONFIDENCE intervals
*COMPARATIVE studies
*OSTEOPOROSIS
*DATA analysis software
*COVID-19
*COMORBIDITY
*PROPORTIONAL hazards models
*DISEASE complications
MORTALITY risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 28226135
- Volume :
- 28
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Endocrinology Research & Practice
- Publication Type :
- Academic Journal
- Accession number :
- 180165003
- Full Text :
- https://doi.org/10.5152/erp.2024.493