Familial Hemophagocytic Lymphohistiocytosis Due to PRF1 Mutation Triggered by Enterovirus.

The article presents a case study of a 6-month-old African American girl diagnosed with familial hemophagocytic lymphohistiocytosis (HLH) triggered by enterovirus, characterized by prolonged fever, pancytopenia, and abnormal liver function. Topics include the diagnostic criteria and challenges of HLH, the therapeutic strategies employed to manage the condition, and genetic underpinnings associated with PRF1 mutations, which affect the perforin protein critical for immune response regulation.