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Mortality and comorbidities in a Nationwide cohort of HIV-infected adults: comparison to a matched non-HIV adults' cohort, France, 2006–18.
- Source :
-
European Journal of Public Health . Oct2024, Vol. 34 Issue 5, p879-884. 6p. - Publication Year :
- 2024
-
Abstract
- Background Human immunodeficiency virus (HIV) remains a significant cause of morbidity and mortality worldwide. The aim of this study was to describe the mortality rate and associated comorbidities in a nationwide population-based cohort of persons living with HIV (PLWHIV) and to compare it with mortality in an age and gender-matched cohort of non-HIV individuals in France. Methods Using data from the French national health data system, we identified and included 173 712 PLWHIV (66.5% men) and 173 712 non-HIV participants (66.5% men) matched for age and gender. PLHIV were identified based on ICD-10 HIV diagnoses, HIV-specific laboratory tests, and/or prescriptions for antiretroviral therapy specific to HIV. Hazard ratios (HRs) of mortality were assessed using multiple Cox regression models. Results During the 13 years of follow-up (2006–18), we observed 20 018 deaths among PLWHIV compared with 6262 deaths among non-HIV participants (11.52% vs. 3.60%, P < 0.001). The over-mortality of PLWHIV was expressed by univariable HR = 2.135 (2.072–2.199), which remained significant after adjustment for region, Complementary Universal Health Insurance and AME, with multivariable HR = 2.182 (2.118–2.248). The results remained significant after adjusting for comorbidities, including infectious diseases [HR = 1.587 (1.538–1.638)]. Notably, PLWHIV were more importantly associated with mortality in women [HR = 2.966 (2.767–3.180)], compared in men [HR = 1.961 (1.898–2.027)]. Conclusion Although the life expectancy of PLWHIV has globally increased, the causes of death should be prioritized in prevention policies and care management. Gender-specific policies should be highlighted, as we observed a higher impact of HIV mortality in women. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEALTH status indicators
*ANTIRETROVIRAL agents
*DEATH
*GENDER specific care
*SEX distribution
*HIV-positive persons
*HEALTH policy
*HIV infections
*AGE distribution
*DESCRIPTIVE statistics
*MULTIVARIATE analysis
*LONGITUDINAL method
*STATISTICS
*COMPARATIVE studies
*COMORBIDITY
*PROPORTIONAL hazards models
*REGRESSION analysis
*ADULTS
Subjects
Details
- Language :
- English
- ISSN :
- 11011262
- Volume :
- 34
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- European Journal of Public Health
- Publication Type :
- Academic Journal
- Accession number :
- 180016878
- Full Text :
- https://doi.org/10.1093/eurpub/ckae031