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Neuroimaging analysis reveals distinct cerebral perfusion responses to fasting‐postprandial metabolic switching in Alzheimer's disease patients.

Authors :
Li, Runzhi
Zhuo, Zhizheng
Yao, Zeshan
Li, Zhaohui
Wang, Yanli
Jiang, Jiwei
Wang, Linlin
Li, Wenyi
Zhang, Yanling
Sun, Jun
Li, Junjie
Duan, Yunyun
Liu, Yi
Shao, Hongyuan
li, Yang
Zhang, Yechuan
Chen, Jinglong
Shi, Hanping
Huang, Hui
Liu, Yaou
Source :
CNS Neuroscience & Therapeutics. Sep2024, Vol. 30 Issue 9, p1-10. 10p.
Publication Year :
2024

Abstract

Aims: Extended fasting–postprandial switch intermitting time has been shown to affect Alzheimer's disease (AD). Few studies have investigated the cerebral perfusion response to fasting–postprandial metabolic switching (FMS) in AD patients. We aimed to evaluate the cerebral perfusion response to FMS in AD patients. Methods: In total, 30 AD patients, 32 mild cognitive impairment (MCI) patients, and 30 healthy control individuals (HCs) were included in the quantification of cerebral perfusion via cerebral blood flow (CBF). The cerebral perfusion response to FMS was defined as the difference (ΔCBF) between fasting and postprandial CBF. Results: Patients with AD had a regional negative ΔCBF in the anterior temporal lobe, part of the occipital lobe and the parietal lobe under FMS stimulation, whereas HCs had no significant ΔCBF. The AD patients had lower ΔCBF values in the right anterior temporal lobe than the MCI patients and HCs. ΔCBF in the anterior temporal lobe was negatively correlated with cognitive severity and cognitive reserve factors in AD patients. Conclusions: AD patients exhibited a poor ability to maintain cerebral perfusion homeostasis under FMS stimulation. The anterior temporal lobe is a distinct area that responds to FMS in AD patients and negatively correlates with cognitive function. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
17555930
Volume :
30
Issue :
9
Database :
Academic Search Index
Journal :
CNS Neuroscience & Therapeutics
Publication Type :
Academic Journal
Accession number :
179998072
Full Text :
https://doi.org/10.1111/cns.70014