Asparaginase for Cancer: From commensal bacteria.

The first article discusses the role of TRPV4 in the production of interleukin 10 (IL-10) during inflammation. The researchers found that TRPV4 activation increased IL-10 production in lung tissue, but did not play a role in resolving inflammation. They also discovered that the transcription factor CREB mediates the production of IL-10. The researchers further investigated the effect of the TRPV4-CREB-IL-10 pathway on mitochondrial health and found that IL-10 has a protective role in maintaining mitochondrial health in macrophages during inflammation.The second article explores the potential use of asparaginase, an enzyme that hydrolyzes asparagine, in cancer treatment. Cancer cells rely on asparagine from the blood to survive and proliferate, so starving them of asparagine can cause them to die. The researchers searched for asparaginase without glutaminase activity among commensal bacteria in the mouth and intestinal tract. They identified bacteria that produce asparaginase without glutaminase activity, which could potentially be used as a treatment for certain cancers.The third article investigates the use of seaweed-derived iron nanoparticles for cancer treatment. The researchers extracted an aqueous extract of a brown seaweed and mixed it with ferric chloride and sodium hydroxide to form stable iron nanoparticles. These nanoparticles showed potential for photocatalytic applications and were effective against liver and pancreatic cancer cells in vitro. Further research is needed to explore their [Extracted from the article]