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No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry.

Authors :
Campagna, Maria Pia
Havrdova, Eva Kubala
Horakova, Dana
Izquierdo, Guillermo
Matesanz, Fuencisla
Eichau, Sara
Lechner-Scott, Jeannette
Taylor, Bruce V
García-Sanchéz, Maria-Isabel
Alcina, Antonio
van der Walt, Anneke
Butzkueven, Helmut
Jokubaitis, Vilija G
Source :
Multiple Sclerosis Journal. Aug2024, Vol. 30 Issue 9, p1216-1220. 5p.
Publication Year :
2024

Abstract

Background: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. Methods: We examined the top variant, rs10191329, from Harroud et al.'s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. Results: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05). Conclusion: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13524585
Volume :
30
Issue :
9
Database :
Academic Search Index
Journal :
Multiple Sclerosis Journal
Publication Type :
Academic Journal
Accession number :
179973548
Full Text :
https://doi.org/10.1177/13524585241240406