七氟烷联合瑞芬太尼对腹股沟斜疝腹腔镜手术患儿苏醒质量、 应激反应和细胞免疫功能的影响.

Objective: To observe the effects of sevoflurane combine with remifentanil on awakening quality, stress response and cellular immune function in children with indirect inguinal hernia undergoing laparoscopic operation. Methods: 102 children with indirect inguinal hernia received in our hospital from November 2023 to January 2024 were divided into control group (51 cases, anesthesia regimen was remifentanil) and observation group (51 cases, anesthesia regimen was Propofol combined with remifentanil) by random number table method. The hemodynamic indexes [heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP)], Awakening situation [time of awakening, extubation and respiratory recovery], stress response indexes (blood glucose and plasma cortisol) and cellular immune function (CD4", CD8", CD4/CD8") were compared in two groups, the incidence of adverse reactions was statistically compared in two groups. Results: HR, SBP and DBP at 10 min after skin incision and extubation in observation group were higher than those in control group (P<0.05). The time of awakening, extubation and respiratory recovery in observation group were shorter than those in control group (P<0.05). The blood glucose and cortisol in observation group were lower than those in control group at the time of skin incision and extubation (P<0.05). 12 h after operation, CD4 and CD4/CD8+ in observation group were higher than those in control group, and CD8 was lower than that in control group (P<0.05). The total incidence of adverse reactions: control group was 9.80%; observation group was 11.76%, there was no difference in two groups (P>0.05). Conclusion: Remifentanil and sevoflurane are selected as anesthetic drugs for children with indirect inguinal hernia undergoing laparoscopic operation, which can maintain hemodynamic stability, improve awakening quality, reduce stress response and relieve immunosuppression. [ABSTRACT FROM AUTHOR]