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Balancing Plk1 activity levels: The secret of synchrony between the cell and the centrosome cycle.

Authors :
Dwivedi, Devashish
Meraldi, Patrick
Source :
BioEssays. Oct2024, Vol. 46 Issue 10, p1-11. 11p.
Publication Year :
2024

Abstract

The accuracy of cell division requires precise regulation of the cellular machinery governing DNA/genome duplication, ensuring its equal distribution among the daughter cells. The control of the centrosome cycle is crucial for the formation of a bipolar spindle, ensuring errorā€free segregation of the genome. The cell and centrosome cycles operate in close synchrony along similar principles. Both require a single duplication round in every cell cycle, and both are controlled by the activity of key protein kinases. Nevertheless, our comprehension of the precise cellular mechanisms and critical regulators synchronizing these two cycles remains poorly defined. Here, we present our hypothesis that the spatiotemporal regulation of a dynamic equilibrium of mitotic kinases activities forms a molecular clock that governs the synchronous progression of both the cell and the centrosome cycles. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02659247
Volume :
46
Issue :
10
Database :
Academic Search Index
Journal :
BioEssays
Publication Type :
Academic Journal
Accession number :
179944585
Full Text :
https://doi.org/10.1002/bies.202400048