Optimal dosage of adamgammadex for reversal of rocuronium-induced neuromuscular block: a preliminary meta-analysis.

This document is a letter published in the journal Systematic Reviews. The letter discusses the optimal dosage of adamgammadex, a reversal agent, for the reversal of rocuronium-induced neuromuscular block. The authors conducted a meta-analysis of three randomized controlled trials comparing different doses of adamgammadex and sugammadex for the reversal of rocuronium-induced neuromuscular blockade. The results suggest that both doses of adamgammadex (4 mg/kg and 6 mg/kg) are effective in reversing neuromuscular blockade, providing flexibility in dosing options for anesthesiologists and surgeons. However, further large-scale trials are needed to confirm these findings and evaluate the safety profile of adamgammadex at different doses. [Extracted from the article]