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Outcomes in Variceal Bleeding Associated With Continuous Octreotide in Patients With Delayed Endoscopy.
- Source :
-
Journal of Pharmacy Practice . Oct2024, Vol. 37 Issue 5, p1107-1115. 9p. - Publication Year :
- 2024
-
Abstract
- Background: Variceal hemorrhage treatment includes endoscopy within 12 hours of admission and octreotide therapy for 2-5 days post-endoscopy. Duration of pre-endoscopy octreotide can be prolonged when intervention is delayed. Objective: This study aimed to evaluate the impact of extended pre-endoscopy octreotide on rebleeding after endoscopy when comparing short vs long durations of post-endoscopy octreotide. Methods: This was a single center, retrospective cohort evaluating adult cirrhotic patients with esophageal variceal hemorrhage admitted between July 1, 2017 and June 30, 2020. Study groups included patients receiving octreotide ≥12 hours prior to endoscopy followed by ≤ 48 (short course) or >48 hours (standard course) after endoscopy. The primary outcome was post-endoscopy rebleeding, defined as hemoglobin decrease of ≥2 g/dL from baseline or the requirement of ≥1 unit of packed red blood cells. Results: Of the 169 patients included, 88 patients received short course octreotide after endoscopy, and 81 patients received standard course octreotide after endoscopy. Twenty-nine (33%) patients in the short course group and 43 (53.1%) in the standard course group experienced the primary endpoint (OR 2.3, 95% CI 1.24 - 4.29; P =.008). Conclusion: Extended pre-endoscopy octreotide may be beneficial in preventing rebleeding when intervention is delayed. Further studies are needed to determine the necessary octreotide duration in delayed endoscopy and varying bleeding risk. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ESOPHAGEAL varices
*GASTROINTESTINAL hemorrhage
*CIRRHOSIS of the liver
*ERYTHROCYTES
*RESEARCH funding
*HEMOGLOBINS
*TREATMENT effectiveness
*RETROSPECTIVE studies
*DESCRIPTIVE statistics
*OCTREOTIDE acetate
*LONGITUDINAL method
*ODDS ratio
*ENDOSCOPIC gastrointestinal surgery
*MEDICAL records
*ACQUISITION of data
*TREATMENT delay (Medicine)
*DISEASE relapse
*CONFIDENCE intervals
*TIME
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 08971900
- Volume :
- 37
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Pharmacy Practice
- Publication Type :
- Academic Journal
- Accession number :
- 179737441
- Full Text :
- https://doi.org/10.1177/08971900241228948