Low mannose‐binding lectin levels is associated with aspirin unresponsiveness in aspirin‐exacerbated respiratory disease.

This article discusses the association between low levels of mannose-binding lectin (MBL) and aspirin unresponsiveness in patients with aspirin-exacerbated respiratory disease (AERD). A retrospective study was conducted on subjects with AERD who underwent immune evaluation and received aspirin therapy after desensitization (ATAD). Among the study subjects, those who did not respond to ATAD had significantly lower MBL levels compared to responders. The authors suggest that MBL deficiency may contribute to the complexity and heterogeneity of AERD and affect the response to ATAD. Further research is needed to validate these findings and explore other factors that may influence aspirin responsiveness in AERD patients. [Extracted from the article]