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Breastfed infants exposed to lamotrigine faced a low risk of toxic effects.

Authors :
Alvarez, Ingrid
Tötterman, Katarina
Honkaniemi, Emma
Sarman, Ihsan
Bäck, Karin
Forsberg, Lisa
Heinonen, Essi Whaites
Svedenkrans, Jenny
Source :
Acta Paediatrica. Sep2024, p1. 9p. 2 Illustrations.
Publication Year :
2024

Abstract

Aim Methods Results Conclusion We aimed to investigate plasma lamotrigine concentrations and clinical effects in infants exposed to lamotrigine through breastfeeding.This was a retrospective study of mother–infant dyads in a clinical follow‐up programme in Stockholm, Sweden. Data were collected from medical records.We included 47 breastfed infants, born from 2011 to 2021, with a median gestational age of 39 + 6 weeks/days and a median birth weight of 3420 g. The median lamotrigine concentration in the infants' plasma was 2.5 (range 2.5–14.0) μmol/L. These concentrations correlated significantly with both the maternal plasma concentrations and the maternal doses (R = 0.79, p < 0.001 versus R = 0.54, p < 0.001). During the follow up, lamotrigine concentrations within the reference range for epilepsy treatment were detected in six (14%) infants and one had clinical symptoms that were probably related to lamotrigine exposure. Liver transaminases were elevated in three of 21 infants. All infants whose mothers had a dose of 150 mg or less had undetectable plasma concentrations and no symptoms during follow up.Infants exposed to lamotrigine through breastfeeding had a low risk of toxic effects. All infants whose mothers had low lamotrigine doses had unmeasurable plasma concentrations and no symptoms of lamotrigine exposure. These low‐risk infants might be offered a simplified follow up. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08035253
Database :
Academic Search Index
Journal :
Acta Paediatrica
Publication Type :
Academic Journal
Accession number :
179725274
Full Text :
https://doi.org/10.1111/apa.17432