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The aging paradox: integrating biological, genetic, epigenetic, and aesthetic insights into skin aging and non-surgical interventions.

Authors :
Webb, William Richard
Rao, Parinitha
Carruthers, Jean D. A.
Rahman, Zakia
Abu-Farsakh, Hany Niamey
Sayed, Karim
Garcia, Patricia E.
Philipp-dormston, Wolfgang
Rahman, Eqram
Source :
European Journal of Plastic Surgery. 9/18/2024, Vol. 47 Issue 1, p1-19. 19p.
Publication Year :
2024

Abstract

Background: The aging paradox highlights the coexistence of increased life expectancy with a persistent desire to maintain a youthful appearance, driven by biological, psychological, and social factors. Advances in healthcare have extended human lifespans, yet societal pressure to appear youthful remains strong. Understanding the genetic, epigenetic, and environmental contributors to skin aging is crucial for optimising aesthetic procedures. Methods: This literature review synthesises research on the aging paradox, genetic influences on skin aging, and the effectiveness of non-surgical aesthetic interventions. The review involved a comprehensive search across databases including PubMed, Google Scholar, Web of Science, and Scopus using keywords like "aging paradox", "genetic imprint", "non-surgical aesthetics", "epigenetics", and "anti-aging treatments". Studies were selected based on relevance, credibility, recency, and diversity of perspectives. Results: The review identified 64 studies relevant to the aging paradox and non-surgical interventions. These studies underscore the significant roles of genetic variations and epigenetic mechanisms, such as DNA methylation and microRNA regulation, in determining aging trajectories and treatment responses. The proposed "PERSONAL" (Personalised Epigenetic Regime for Skin Optimisation, Nurturing Aesthetic Longevity) paradigm advocates for a comprehensive, personalised approach, integrating genetic and epigenetic profiling to tailor treatments to individual needs. Conclusions: By leveraging the complex interplay of genetic, epigenetic, and environmental factors, practitioners can enhance the precision and efficacy of non-surgical aesthetic interventions, improving patient satisfaction and promoting long-term skin health. Continuous monitoring and iterative adjustments within this paradigm are essential for achieving optimal outcomes. Level of evidence: Level 4, therapeutic study [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
0930343X
Volume :
47
Issue :
1
Database :
Academic Search Index
Journal :
European Journal of Plastic Surgery
Publication Type :
Academic Journal
Accession number :
179711534
Full Text :
https://doi.org/10.1007/s00238-024-02239-5