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The aging paradox: integrating biological, genetic, epigenetic, and aesthetic insights into skin aging and non-surgical interventions.
- Source :
-
European Journal of Plastic Surgery . 9/18/2024, Vol. 47 Issue 1, p1-19. 19p. - Publication Year :
- 2024
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Abstract
- Background: The aging paradox highlights the coexistence of increased life expectancy with a persistent desire to maintain a youthful appearance, driven by biological, psychological, and social factors. Advances in healthcare have extended human lifespans, yet societal pressure to appear youthful remains strong. Understanding the genetic, epigenetic, and environmental contributors to skin aging is crucial for optimising aesthetic procedures. Methods: This literature review synthesises research on the aging paradox, genetic influences on skin aging, and the effectiveness of non-surgical aesthetic interventions. The review involved a comprehensive search across databases including PubMed, Google Scholar, Web of Science, and Scopus using keywords like "aging paradox", "genetic imprint", "non-surgical aesthetics", "epigenetics", and "anti-aging treatments". Studies were selected based on relevance, credibility, recency, and diversity of perspectives. Results: The review identified 64 studies relevant to the aging paradox and non-surgical interventions. These studies underscore the significant roles of genetic variations and epigenetic mechanisms, such as DNA methylation and microRNA regulation, in determining aging trajectories and treatment responses. The proposed "PERSONAL" (Personalised Epigenetic Regime for Skin Optimisation, Nurturing Aesthetic Longevity) paradigm advocates for a comprehensive, personalised approach, integrating genetic and epigenetic profiling to tailor treatments to individual needs. Conclusions: By leveraging the complex interplay of genetic, epigenetic, and environmental factors, practitioners can enhance the precision and efficacy of non-surgical aesthetic interventions, improving patient satisfaction and promoting long-term skin health. Continuous monitoring and iterative adjustments within this paradigm are essential for achieving optimal outcomes. Level of evidence: Level 4, therapeutic study [ABSTRACT FROM AUTHOR]
- Subjects :
- *SKIN aging
*GENOMIC imprinting
*RNA regulation
*DERMAL fillers
*BOTULINUM toxin
Subjects
Details
- Language :
- English
- ISSN :
- 0930343X
- Volume :
- 47
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- European Journal of Plastic Surgery
- Publication Type :
- Academic Journal
- Accession number :
- 179711534
- Full Text :
- https://doi.org/10.1007/s00238-024-02239-5