化生性乳腺癌临床病理特征及诊疗分析.

Objective To investigate the clinicopathologic features and diagnostic of metaplastic breast cancer (MpBC). Methods A retrospective analysis of the clinical data of 46 patients with pathologically confirmed MpBC admitted to the hospital from January 2014 to December 2022 was performed to analyze their clinicopathological features, outcomes and survival. The median follow-up time was 50. 9 months. Results A total of 46 patients with median age of 52 years were female. The molecular subtype was triple-negative in 80. 4% (37/46) of the patients, with spindle cell carcinoma being the most common histological subtype [32. 6% (15/46)]. All 46 patients underwent surgical treatment, and the most common distant metastasis was to the lungs [57. 1% (8/14)]. The 3-year and 5-year progression-free survival rates were 78. 0% and 61. 3%, respectively. The 3-year and 5-year overall survival rates were 82. 9% and 64. 3%, respectively. Tumor pathological grade 3, lymph node metastasis, and Ki-67＞50% were the risk factors for the prognosis of MpBC patients (P＜0. 05). Ki-67＞50% was an independent risk factor for the prognosis of MpBC patients (P＜0. 05). Conclusion MpBC progresses rapidly, and poor overall survival, surgical excision is the treatment excision for MpBC, and Ki-67＞50% is an independent risk factor for its prognostic. [ABSTRACT FROM AUTHOR]