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Effects of Phytoncide Fragrance on Resting-State Brain Activity in Mild Cognitive Impairment: A Randomized Double-Blind Controlled Study.
- Source :
-
Journal of Integrative & Complementary Medicine . Sep2024, Vol. 30 Issue 9, p848-857. 10p. - Publication Year :
- 2024
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Abstract
- Introduction: The therapeutic potential of phytoncide fragrances may be optimal for patients with mild cognitive impairment (MCI) that display complex symptomatology. This study aimed to explore the clinical value of phytoncide by evaluating its electrophysiological effects in patients with MCI. Materials and Methods: This was a double-blind, randomized controlled trial. A total of 24 community-dwelling patients were randomly assigned to either a phytoncide or no-odor group. Participants wore a dental mask, for 30 min at rest that had either the fragrance stimulus or water added to it. The quantitative electroencephalography (EEG) during the resting state was recorded before and after a single intervention. Results: There were significant interaction effects in absolute EEG-power values in the occipital (F = 6.52, p = 0.018) and parietal (F = 5.41, p = 0.030) left hemisphere at β frequency. Phytoncide odor significantly decreased low and high β activity in the occipital (corrected p = 0.009) and parietal (corrected p = 0.047) left hemisphere, respectively. In source localization, phytoncide odor significantly decreased deep source activation in the left inferior and middle frontal gyri at β 2 frequency band compared with the no-odor group (threshold = 4.25, p < 0.05). Conclusions: Reductions in β, indicative of anxiety, depression, and stress, suggest relief from emotion-related symptoms that are common in patients with MCI. Trial Registration: Clinical Trials Registry Korea (registration: KCT0007317). [ABSTRACT FROM AUTHOR]
- Subjects :
- *COGNITION disorders treatment
*REPEATED measures design
*STATISTICAL power analysis
*RESEARCH funding
*ACADEMIC medical centers
*BRAIN
*BLIND experiment
*STATISTICAL sampling
*ELECTROENCEPHALOGRAPHY
*TREATMENT effectiveness
*RANDOMIZED controlled trials
*PHYTOCHEMICALS
*DISEASE remission
*DESCRIPTIVE statistics
*PLANT extracts
*SMELL
*GAS chromatography
*MEDICINAL plants
*COGNITION disorders
*MASS spectrometry
*ANALYSIS of variance
*ORGANIC compounds
*PSYCHIATRIC hospitals
*DATA analysis software
*ELECTROPHYSIOLOGY
*RELAXATION for health
*EVALUATION
Subjects
Details
- Language :
- English
- ISSN :
- 27683605
- Volume :
- 30
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Integrative & Complementary Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 179688176
- Full Text :
- https://doi.org/10.1089/jicm.2023.0185