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Sex and disease regulate major histocompatibility complex class I expression in human lung epithelial cells.
- Source :
-
Physiological Reports . Sep2024, Vol. 12 Issue 17, p1-18. 18p. - Publication Year :
- 2024
-
Abstract
- Major histocompatibility complex class I (MHC I) molecules present peptides to CD8+ T‐cells for immunosurveillance of infection and cancer. Recent studies indicate lineage‐specific heterogeneity in MHC I expression. While respiratory diseases rank among the leading causes of mortality, studies in mice have shown that lung epithelial cells (LECs) express the lowest levels of MHC I in the lung. This study aims to answer three questions: (i) Do human LECs express low levels of MHC I? (ii) Is LEC MHC I expression modulated in chronic respiratory diseases? (iii) Which factors regulate MHC I levels in human LECs? We analyzed human LECs from parenchymal explants using single‐cell RNA sequencing and immunostaining. We confirmed low constitutive MHC I expression in human LECs, with significant upregulation in chronic respiratory diseases. We observed a sexual dimorphism, with males having higher MHC I levels under steady‐state conditions, likely due to differential redox balance. Our study unveils the complex interplay between MHC I expression, sex, and respiratory disease. Since MHC I upregulation contributes to the development of immunopathologies in other models, we propose that it may have a similar impact on chronic lung disease. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 2051817X
- Volume :
- 12
- Issue :
- 17
- Database :
- Academic Search Index
- Journal :
- Physiological Reports
- Publication Type :
- Academic Journal
- Accession number :
- 179687988
- Full Text :
- https://doi.org/10.14814/phy2.70025