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A Randomized Controlled Trial to Determine the Impact of Resistance Training versus Aerobic Training on the Management of FGF-21 and Related Physiological Variables in Obese Men with Type 2 Diabetes Mellitus.
- Source :
-
Journal of Sports Science & Medicine . Sep2024, Vol. 23 Issue 3, p495-503. 9p. - Publication Year :
- 2024
-
Abstract
- Fibroblast growth factor 21 (FGF-21) has been suggested as a potential therapeutic target for insulin resistance in health-related metabolic disorders such as type 2 diabetes. Despite the metabolic effects of resistance (RT) and aerobic training (AT) on diabetes symptoms, uncertainty exists regarding the superiority of effects manifested through these training approaches on FGF-21 and biochemical and physiological variables associated with metabolic disorders in men diagnosed with type 2 diabetes. This study aimed to investigate the impact of a 12-week RT and AT on FGF-21 levels and symptoms associated with metabolic disorders in male individuals diagnosed with type 2 diabetes. Thirty-six sedentary obese diabetic men (40 to 45 years old) were matched based on the level of FGF-1. They and were randomly divided into two training groups (RT, n = 12 and AT, n = 12) performing three days per week of moderate-intensity RT or AT for 12 weeks and an inactive control group (n = 12). Both training interventions significantly improved FGF-21, glucose metabolism, lipid profile, hormonal changes, strength, and aerobic capacity. Subgroup analysis revealed that RT had greater adaptive responses (p < 0.01) in fasting blood sugar (ES = -0.52), HOMA-IR (ES = -0.87), testosterone (ES = 0.52), cortisol (ES = -0.82), FGF-21 (ES = 0.61), and maximal strength (ES = 1.19) compared to AT. Conversely, AT showed greater changes (p < 0.01) in cholesterol (ES = -0.28), triglyceride (ES = -0.64), HDL (ES = 0.46), LDL (ES = -0.73), and aerobic capacity (ES = 1.18) compared to RT. Overall, both RT and AT interventions yielded significant moderate to large ES in FGF-21 levels and enhanced the management of biochemical variables. RT is an effective method for controlling FGF-21 levels and glucose balance, as well as for inducing hormonal changes. On the other hand, AT is more suitable for improving lipid profiles in overweight men with type 2 diabetes mellitus. [ABSTRACT FROM AUTHOR]
- Subjects :
- *OBESITY treatment
*METABOLIC disorder treatment
*STATISTICAL power analysis
*HDL cholesterol
*RESEARCH funding
*RADIOIMMUNOASSAY
*GLYCOSYLATED hemoglobin
*STATISTICAL sampling
*QUESTIONNAIRES
*ENZYME-linked immunosorbent assay
*SEDENTARY lifestyles
*LIPIDS
*TREATMENT effectiveness
*RANDOMIZED controlled trials
*DESCRIPTIVE statistics
*AEROBIC capacity
*LDL cholesterol
*RESISTANCE training
*CONTROL groups
*PRE-tests & post-tests
*MUSCLE strength
*BLOOD sugar
*TYPE 2 diabetes
*AEROBIC exercises
*FIBROBLAST growth factors
*MEN'S health
*ANALYSIS of variance
*CHOLESTEROL
*COMPARATIVE studies
*DATA analysis software
*CONFIDENCE intervals
*TRIGLYCERIDES
*PHYSICAL activity
Subjects
Details
- Language :
- English
- ISSN :
- 13032968
- Volume :
- 23
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Journal of Sports Science & Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 179686694
- Full Text :
- https://doi.org/10.52082/jssm.2024.495