Interaction Effect of Shift Work and Insomnia on Stroke Risk: A 19-Year Prospective Cohort Study in Korea.

Objectives: Our study aimed to investigate the association between shift work and stroke and determinewhether this association varies depending on the presence of insomnia. Methods: Utilizing the KoGES prospective cohort data, our primary exposure variables were shift work and insomnia. The occurrence of strokewas themain outcome of interest. Hazards ratios and 95%confidence intervals were estimated using Cox regression analysis. An interaction analysis was conducted to assess the interaction of shift work and insomnia on stroke incidence. Results: In the interaction analysis, shift work was significantly associated with stroke incidence only in groupswith insomnia and a hazards ratio of 2.49 (95% confidence interval, 1.02-6.11). Conclusions: Our study demonstrated that shift work was associated with a higher risk of stroke among the population with insomnia. [ABSTRACT FROM AUTHOR]