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Lipid Nanoparticles for Nucleic Acid Delivery Beyond the Liver.
- Source :
-
Human Gene Therapy . 2024, Vol. 35 Issue 17/18, p617-627. 11p. - Publication Year :
- 2024
-
Abstract
- Lipid nanoparticles (LNPs) are the most clinically advanced drug delivery system for nucleic acid therapeutics, exemplified by the success of the COVID-19 mRNA vaccines. However, their clinical use is currently limited to hepatic diseases and vaccines due to their tendency to accumulate in the liver upon intravenous administration. To fully leverage their potential, it is essential to understand and address their liver tropism, while also developing strategies to enhance delivery to tissues beyond the liver. Ensuring that these therapeutics reach their target cells while avoiding off-target cells is essential for both their efficacy and safety. There are three potential targeting strategies—passive, active, and endogenous—which can be used individually or in combination to target nonhepatic tissues. In this review, we delve into the recent advancements in LNP engineering for delivering nucleic acid beyond the liver. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10430342
- Volume :
- 35
- Issue :
- 17/18
- Database :
- Academic Search Index
- Journal :
- Human Gene Therapy
- Publication Type :
- Academic Journal
- Accession number :
- 179663320
- Full Text :
- https://doi.org/10.1089/hum.2024.106