Junctophilin-2 Regulates Mitochondrial Metabolism.

This research letter discusses the role of junctophilin-2 (JPH2) in regulating mitochondrial metabolism and its potential impact on right ventricular dysfunction (RVD). RVD is a risk factor for death in various cardiovascular diseases, but effective therapies are lacking. JPH2 is an essential protein involved in calcium handling and maintaining the structure of cardiomyocytes. It may also play a role in mitochondrial function. The study found that JPH2 interacts with a mitochondrial protein called MFN2 and that impaired mitochondrial metabolism contributes to RVD. The findings suggest that targeting JPH2 could potentially improve outcomes in cardiac conditions associated with RVD. [Extracted from the article]